Related Experiment Video

Updated: Jun 17, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Chronic non-transmural infarction has a delayed recovery of function following revascularization

Martin Ugander1, Peter A Cain, Per Johnsson

  • 1Department of Clinical Physiology, Lund University Hospital, Lund University, Lund, SE-221 85 Sweden.

BMC Cardiovascular Disorders
|January 20, 2010
PubMed

Insights

Myocardial segments without infarction recover function within one month after revascularization. Segments with non-transmural infarction show delayed functional recovery between one and six months post-revascularization.

Area of Science:

  • Cardiovascular Imaging and Intervention
  • Myocardial Perfusion and Function Assessment

Background:

  • The temporal dynamics of regional functional recovery after revascularization, particularly concerning the presence and extent of myocardial infarction, remain incompletely understood.
  • This study investigates how chronic non-transmural infarction influences the recovery trajectory of myocardial perfusion and function following elective revascularization procedures.

Purpose of the Study:

  • To elucidate the time course of regional myocardial functional recovery after revascularization.
  • To compare recovery patterns in dysfunctional myocardial segments with and without infarction.
  • To assess the impact of non-transmural infarction on the speed and extent of perfusion and function restoration.

Main Methods:

  • Prospective study involving 18 patients undergoing elective coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI).
  • Utilized cine magnetic resonance imaging (MRI), delayed contrast-enhanced MRI, and 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) at baseline, one month, and six months post-intervention.
  • Analyzed 337 dysfunctional myocardial segments, classifying them based on the presence (n=164) or absence (n=173) of infarction, with a focus on non-transmural infarcts (31% +/- 22% transmurality).

Main Results:

  • Segments without infarction showed significant improvements in quantitative stress perfusion and wall thickening by one month post-revascularization, with no further gains at six months.
  • Segments with non-transmural infarction demonstrated improved stress perfusion at one month, but wall thickening recovery was slower and less pronounced at both one (p < 0.05) and six months (p < 0.001).
  • Dysfunctional segments without infarction represent stunned or hibernating myocardium, achieving full recovery within one month.

Conclusions:

  • Dysfunctional segments without infarction recover perfusion and function rapidly within one month after revascularization.
  • Non-transmural infarction leads to a delayed functional recovery between one and six months, suggesting a more significant ischemic insult.
  • These findings are crucial for clinical evaluation of regional functional recovery timelines post-revascularization, differentiating recovery based on infarction presence and extent.
Abstract

More Related Videos

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...