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Related Experiment Video

Updated: Jun 17, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

Gene expression profiling in head and neck squamous cell carcinoma.

Boudewijn J M Braakhuis1, Ruud H Brakenhoff, C René Leemans

  • 1Department of Otolaryngology - Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands. bjm.braakhuis@vumc.nl

Current Opinion in Otolaryngology & Head and Neck Surgery
|January 20, 2010
PubMed
Summary

Micro-array expression profiling for head and neck squamous cell carcinoma shows limited predictive value currently. Further validation in large patient groups is needed before clinical implementation for cancer patients.

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Area of Science:

  • Oncology
  • Genomics
  • Biomarkers

Background:

  • Micro-array expression profiling is explored for predictive and prognostic insights in head and neck squamous cell carcinoma (HNSCC).
  • Recent literature provides a critical update on the utility of gene expression profiling in HNSCC.

Purpose of the Study:

  • To critically review recent publications on micro-array expression profiling in HNSCC.
  • To assess the current predictive and prognostic value of gene expression profiling for HNSCC patients.

Main Methods:

  • Review of recent publications on micro-array expression profiling in HNSCC.
  • Analysis of described gene profiles and their predictive capabilities.

Main Results:

  • Several gene profiles (4-825 genes) have been identified, focusing on predicting survival, lymph node, and distant metastases.

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Published on: March 11, 2014

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Last Updated: Jun 17, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

  • Limited overlap between studies suggests variability due to platforms, tumor subtypes, and analytical methods.
  • Validation of the identified gene profiles has been suboptimal.

    • Conclusions:

    • Micro-array expression profiling currently offers no clinical benefit for HNSCC patients.
    • Clinical implementation requires robust validation in large, uniform patient cohorts.
    • Future success depends on translating findings into cost-effective, practical assays for routine practice.