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QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii
Published on: June 22, 2017
[Toxoplasmosis in Sfax, Tunisia]
H Sellami1, H Amri, F Cheikhrouhou
1Laboratoire de parasitologie-mycologie, CHU Habib-Bourguiba, Sfax, Tunisie. ali.ayadi@rns.tn
Bulletin De La Societe De Pathologie Exotique (1990)
|January 20, 2010
Summary
Toxoplasmosis affects pregnant women, immunocompromised individuals, and those with lymphadenopathy or ocular issues. This study highlights the diverse clinical presentations and seroprevalence in Tunisia, emphasizing the need for accurate diagnosis.
Area of Science:
- Medical Parasitology
- Infectious Diseases
- Epidemiology
Context:
- Toxoplasmosis prevalence varies with lifestyle and environment.
- Tunisia presents a unique epidemiological setting for studying toxoplasmosis.
- Long-term data collection (1994-2006) provides a robust dataset.
Purpose:
- To investigate the epidemiological, clinical, and biological aspects of toxoplasmosis in Sfax, Tunisia.
- To determine the seroprevalence of toxoplasmosis in pregnant women.
- To analyze toxoplasmosis in immunocompromised patients and those with specific clinical manifestations.
Summary:
- Retrospective analysis of 40,566 pregnant women showed a 39.3% seroprevalence.
- Active toxoplasmosis during pregnancy occurred in 1.3%, with 16 congenital cases detected.
- Toxoplasmosis was confirmed in 13.7% of lymphadenitis cases, 11.7% of HIV-positive patients (revealing 4 HIV cases), and one renal transplant recipient.
- 21 patients with ocular toxoplasmosis (retinochoroiditis) were treated.
Impact:
- Highlights the significant burden of toxoplasmosis in a Tunisian population.
- Underscores the importance of serological screening in pregnant and immunocompromised individuals.
- Demonstrates the diverse clinical spectrum of toxoplasmosis, necessitating careful bioclinical correlation for diagnosis.
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