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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jun 16, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Angiogenesis in asthma.

D Ribatti1, I Puxeddu, E Crivellato

  • 1Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. ribatti@anatomia.uniba.it

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|January 21, 2010
PubMed
Summary
This summary is machine-generated.

Asthma involves airway inflammation and structural changes like fibrosis and angiogenesis. This review explores how allergic inflammation drives airway vascularity and potential treatments targeting these bronchial microvascular changes.

More Related Videos

Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Related Experiment Videos

Last Updated: Jun 16, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Pathology

Background:

  • Asthma is a chronic airway inflammatory disease.
  • Characterized by inflammatory cell infiltration and structural changes like subepithelial fibrosis, smooth muscle hypertrophy, and angiogenesis.
  • These changes correlate with asthma severity and progressive lung function decline.

Purpose of the Study:

  • To review recent data on airway angiogenesis in asthma.
  • To elucidate the mechanisms underlying airway vascular changes in asthma.
  • To explore potential therapeutic strategies targeting bronchial microvascular alterations.

Main Methods:

  • Literature review of recent studies on asthma pathophysiology.
  • Analysis of data linking allergic inflammation to airway vascularity.
  • Evaluation of therapeutic approaches targeting microvascular changes.

Main Results:

  • Allergic inflammation contributes significantly to increased airway vascularity in asthma.
  • Airway angiogenesis is a key feature associated with asthma severity.
  • Bronchial microvascular remodeling plays a role in disease progression.

Conclusions:

  • Understanding the role of allergic inflammation in airway angiogenesis is crucial for asthma management.
  • Targeting bronchial microvascular changes offers potential therapeutic avenues for asthma treatment.
  • Further research is needed to fully elucidate the clinical relevance of airway vascularity in asthma.