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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
05:23

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Published on: March 7, 2025

Clinical and biochemical parameters related to cardiovascular disease after Helicobacter pylori eradication

R Pellicano1, E Oliaro, S Fagoonee

  • 1Gastro-Hepatology Unit, S. Giovanni Battista (Molinette) Hospital, Turin, Italy. rinaldo_pellican@hotmail.com

International Angiology : a Journal of the International Union of Angiology
|January 21, 2010
PubMed

Insights

Eradicating Helicobacter pylori (H.pylori) infection improved cardiovascular risk factors like HDL-C and C-reactive protein. This suggests a potential link between H.pylori and ischemic heart disease (IHD) risk, warranting further research.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Microbiology

Background:

  • Established risk factors do not fully explain ischemic heart disease (IHD) pathogenesis.
  • A potential link between Helicobacter pylori (H.pylori) infection and IHD exists, but mechanisms are unclear.
  • H.pylori may influence IHD through proinflammatory or metabolic pathways.

Purpose of the Study:

  • To investigate the impact of H.pylori eradication on clinical and biochemical parameters associated with IHD.
  • To assess changes in cardiovascular risk markers following successful H.pylori treatment.

Main Methods:

  • A cohort of 496 patients with H.pylori-positive dyspepsia/peptic ulcer disease underwent eradication therapy.
  • Clinical (BMI, diastolic blood pressure) and biochemical (CRP, fibrinogen, lipids, glucose) parameters were measured pre-eradication and annually for up to five years.
  • Statistical analysis utilized the Student's t test to compare pre- and post-eradication values.

Main Results:

  • High-density lipoprotein cholesterol (HDL-C) significantly increased (P=0.02).
  • C-reactive protein and fibrinogen levels significantly decreased (P<0.0001).
  • Body mass index (BMI) and diastolic blood pressure showed significant increases (P=0.032 and P=0.039, respectively).

Conclusions:

  • H.pylori eradication is associated with favorable changes in several IHD-related clinical and biochemical parameters.
  • The findings suggest a potential role of H.pylori in cardiovascular health.
  • Further large-scale, randomized interventional studies are necessary to establish a causal relationship between H.pylori and IHD.
Abstract

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