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Updated: Jun 16, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Pd-catalyzed oxidative coupling with organometallic reagents via C-H activation
Chang-Liang Sun1, Bi-Jie Li, Zhang-Jie Shi
1Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing, China.
Abstract:
Direct selective palladium catalyzed C-H functionalization has become a highly attractive strategy in organic synthesis and represents a highly desirable goal. Compared with cross-coupling reactions of C-H bonds with aryl or alkyl halides/pseudohalides, the strategy of cross-coupling reactions of C-H bonds with organometallic reagents is of great significance and obvious advantages. This feature article provides a comprehensive summary of recent advances and an intensive analysis on Pd-catalyzed C-H activation and oxidative coupling with various organometallic reagents.
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