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High-energy shock waves: in vitro effects.

R V Clayman1, S Long, M Marcus

  • 1Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|April 1, 1991
PubMed
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High-energy shock waves (HESW) damage cells in vitro by causing cavitation and shear forces. This damage affects cell membranes and organelles, particularly mitochondria, regardless of cell doubling time.

Area of Science:

  • Biophysics
  • Cell Biology
  • Biotechnology

Background:

  • Numerous studies investigate high-energy shock waves (HESW) effects on cells in vitro.
  • Comparing studies is challenging due to variable experimental conditions.
  • Focusing on studies with controlled variables enables understanding HESW's cellular impact.

Purpose of the Study:

  • To review and synthesize existing literature on HESW effects on cells in vitro.
  • To identify consistent findings regarding cellular damage mechanisms.
  • To explore potential clinical applications of HESW in cancer therapy.

Main Methods:

  • Comprehensive literature review of in vitro studies on HESW and cells.
  • Selection of studies with defined and controlled experimental variables.

Related Experiment Videos

  • Analysis of reported cellular damage and affected organelles.

    • Main Results:

    • HESW induce cellular damage irrespective of cell doubling time.
    • Damage mechanisms involve cavitation, shear forces, and jets.
    • Mitochondria are highly sensitive, with damage also observed in the nucleus and endoplasmic reticulum.

    Conclusions:

    • HESW cause significant in vitro cellular damage through physical forces.
    • Mitochondrial damage is a key finding, alongside effects on other organelles.
    • In vitro combination therapy of HESW and chemotherapy shows promise but requires further in vivo validation.