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Updated: Feb 9, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

[From haematoma to sarcoma].

Tania Podlaska Mariager¹, Marianne Nygaard, Mostafa Benyahia

¹Glostrup Hospital, Ortopaedkirurgisk Afdeling, Denmark. annatania@gmail.com

Ugeskrift for Laeger

|January 22, 2010

Summary

This summary is machine-generated.

Consider extremity sarcoma in patients with persistent thigh masses after minor trauma. Delayed diagnosis is common, with symptoms worsening over time, indicating a need for vigilance.

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Area of Science:

Orthopedic Oncology
Musculoskeletal Radiology
Diagnostic Imaging

Background:

Soft tissue masses in the thigh are often initially misdiagnosed as benign conditions like muscle strains or hematomas.
Minor trauma can sometimes mask or trigger the presentation of underlying neoplastic processes.

Observation:

Two cases presented with asymptomatic thigh masses initially attributed to trauma.
Over several months, patients developed severe systemic symptoms including fever, anemia, and elevated inflammatory markers.

Findings:

Both cases were ultimately diagnosed with extremity sarcoma, highlighting a common delay in diagnosis.
Key indicators for sarcoma include long-standing duration, pain disproportionate to trauma, deep fascial involvement, size > 5 cm, rapid growth, fixation, and solid consistency.

Implications:

Emphasizes the importance of considering sarcoma in the differential diagnosis of persistent or worsening thigh masses.
Highlights the need for advanced imaging and potentially biopsy in cases with concerning features to avoid diagnostic delays.