Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biliary response to glucagon in humans.

G D Branum1, B A Bowers, C R Watters

  • 1Department of Surgery, Duke University, Durham, North Carolina.

Annals of Surgery
|April 1, 1991
PubMed
Summary

Glucagon significantly increases bile flow and reduces cholesterol and phospholipid output in humans. This hormone plays a key role in the physiological regulation of biliary secretion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subcutaneous emphysema during mandibular wisdom tooth extraction: Cases series.

Annals of medicine and surgery (2012)·2021
Same author

Randomized study on the effect of single-implant versus two-implant retained overdentures on implant loss and muscle activity: a 12-month follow-up report.

International journal of oral and maxillofacial surgery·2017
Same author

Optical properties of Lead bismuth borate glasses doped with neodymium oxide.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2015
Same author

Safety of pediatric continuous interscalene block catheters placed under general anesthesia: a single center's experience.

Acta anaesthesiologica Scandinavica·2015
Same author

The value of ultrasonography in the diagnosis of appendicitis.

International journal of surgery (London, England)·2014
Same author

The PRIMARA study: a prospective, descriptive, observational study to review cinacalcet use in patients with primary hyperparathyroidism in clinical practice.

European journal of endocrinology·2014

Area of Science:

  • Hepatology
  • Gastroenterology
  • Endocrinology

Background:

  • Glucagon is known to influence biliary secretion in various species.
  • Its specific role in human biliary physiology requires further elucidation.

Purpose of the Study:

  • To investigate the effects of glucagon on human biliary secretion.
  • To analyze changes in bile composition following glucagon administration.

Main Methods:

  • Study conducted on nine patients post-biliary tract surgery with T-tube drainage.
  • Bile flow, cholesterol, and phospholipid output were measured.
  • Enterohepatic circulation was maintained via T-tube reinfusion.
  • Bile acid profiles analyzed using high-performance liquid chromatography.

Related Experiment Videos

Main Results:

  • Glucagon administration led to increased bile flow.
  • A decrease in cholesterol and phospholipid output was observed.
  • No significant alterations in bile salt species or conjugation were detected.

Conclusions:

  • Glucagon administration enhances bile flow and alters lipid output in humans.
  • Glucagon is likely involved in the physiological regulation of human biliary secretion.