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Updated: Jun 16, 2026
Transplantation Into the Mouse Ovarian Fat Pad
Published on: September 7, 2016
Significance of preoperative thrombocytosis in epithelial ovarian cancer
Julian A Crasta1, T S Premlatha, Suniti M Krishnan
1Department of Pathology, St. John's Medical College and Hospital, Sarjapur Road, Bangalore 560 034, Karnataka, India.
Background:
Reactive thrombocytosis is reported in a variety of solid tumors. A few studies have documented preoperative thrombocytosis in ovarian cancer and identified it as a marker of aggressive tumor biology.
Aim:
To study the incidence of preoperative thrombocytosis (platelets greater than 400x10) in epithelial ovarian cancer and its association with other clinicopathologic factors.
Materials And Methods:
Sixty-five patients with invasive ovarian epithelial cancer were retrospectively reviewed and analyzed for the association preoperative thrombocytosis with other clinical and histopathological prognostic factors. Means were analyzed by Student's t test; proportions were determined by Chi-square analysis.
Results:
Twenty of 65 (37.5%) patients had thrombocytosis at primary diagnosis. Patients with preoperative thrombocytosis were found to have lower hemoglobin (P < 0.0002), more advanced stage disease (P < 0.05) and higher grade tumors (P < 0.02). Patients with thrombocytosis had greater likelihood of subpotimal cytoreduction.
Conclusions:
Preoperative thrombocytosis is a frequent finding in ovarian carcinomas and their association with advanced stage disease and higher grade denotes that platelets play a role in the tumor growth and progression.
