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A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
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A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

Published on: August 27, 2015

Mammalian cell-based sensor system.

Pratik Banerjee1, Briana Franz, Arun K Bhunia

  • 1Laboratory of Food Microbiology & Immunochemistry, Department of Food & Animal Sciences, Alabama A&M University, Normal, AL, 35762, USA.

Advances in Biochemical Engineering/Biotechnology
|January 22, 2010
PubMed
Summary
This summary is machine-generated.

Mammalian cell-based biosensors (CBBs) utilize living cells for functional diagnostics and toxicity testing. These CBBs offer a promising approach for detecting pathogens and toxins in various samples.

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Area of Science:

  • Biomedical Engineering
  • Biosensor Technology
  • Cellular Diagnostics

Background:

  • Living cells are increasingly used in biosensors, creating a new field of functional diagnostics.
  • Mammalian cell-based biosensors (CBBs) employ mammalian cells as the core biorecognition element.
  • Cell-based assays are established for high-throughput screening (HTS) and cytotoxicity testing.

Purpose of the Study:

  • To explore the types and applications of mammalian cell-based sensor systems.
  • To highlight the utility of CBBs in functional diagnostics and sample analysis.
  • To discuss the mechanisms by which CBBs detect analytes.

Main Methods:

  • Utilizing mammalian cells as biorecognition elements in biosensors.
  • Measuring analyte-induced changes in cellular activities via electrical impedance or optical devices.
  • Detecting cellular responses such as apoptosis or necrosis.

Main Results:

  • CBBs can screen, monitor, and measure analyte-induced changes in cellular functions.
  • These biosensors can report the presence of active components like pathogens or toxins.
  • Electrical and optical detection methods are employed to measure cellular responses.

Conclusions:

  • Mammalian cell-based biosensors represent a significant advancement in functional diagnostics.
  • CBBs provide a versatile platform for detecting a range of analytes in clinical, environmental, and food safety applications.
  • The integration of cellular functions with sensor technology offers powerful analytical capabilities.