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Antiasthma Drugs: Methylxanthines

Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
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Acupuncture in a Rat Model of Asthma
07:14

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Published on: August 25, 2020

Caffeine for asthma.

Emma J Welsh1, Anna Bara, Elizabeth Barley

  • 1Community Health Sciences, St George's, University of London, Cranmer Terrace, London, UK, SW17 0RE.

The Cochrane Database of Systematic Reviews
|January 22, 2010
PubMed
Summary
This summary is machine-generated.

Caffeine intake appears to modestly improve lung function in asthma patients for up to four hours. Asthmatics may need to avoid caffeine before lung function tests to prevent inaccurate results.

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Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Clinical Trials

Background:

  • Caffeine, a weak bronchodilator chemically related to theophylline, is being investigated for its potential to alleviate asthma symptoms.
  • Existing research on caffeine's effects in asthma warrants systematic review to consolidate evidence.

Purpose of the Study:

  • To evaluate the impact of caffeine on lung function in individuals with asthma.
  • To determine if caffeine consumption influences exhaled nitric oxide levels.
  • To assess the necessity of controlling caffeine intake before pulmonary function tests.

Main Methods:

  • Systematic review of randomized clinical trials comparing oral caffeine to placebo or coffee to decaffeinated coffee in adults with asthma.
  • Searched Cochrane Airways Group trials register and article reference lists; contacted study authors.
  • Independent data extraction and quality assessment by two reviewers.

Main Results:

  • Seven cross-over trials with 75 participants showed caffeine improved lung function for up to two hours.
  • Forced expiratory volume in one minute (FEV1) showed a small improvement (mean difference 5%, with some studies showing 12-18%) up to two hours post-ingestion.
  • Mid-expiratory flow rates improved with caffeine for up to four hours; no significant effect on exhaled nitric oxide levels was observed.

Conclusions:

  • Caffeine demonstrates a modest, short-term improvement in airway function for individuals with asthma.
  • Avoiding caffeine for at least four hours before lung function testing is recommended to ensure accurate results.
  • Further research is needed to confirm the lack of effect of caffeinated coffee on exhaled nitric oxide measurements.