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Updated: Jun 16, 2026
04:11
Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease
Published on: April 28, 2023
Surgery for Ménière's disease
Bas Pullens1, Johan Lodewijk Giard, Hendrik P Verschuur
1ENT Surgery, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584 CX.
The Cochrane Database of Systematic Reviews
|January 22, 2010
Summary
Surgical options for Ménière's disease lack sufficient evidence of effectiveness. Endolymphatic sac surgery, the only intervention studied in randomized trials, showed no benefit compared to placebo or ventilation tubes.
Area of Science:
- Otolaryngology
- Neurosurgery
- Evidence-based medicine
Background:
- Ménière's disease presents with variable vertigo, deafness, and tinnitus.
- Surgical treatments aim to alleviate symptoms but their efficacy is uncertain.
Purpose of the Study:
- To evaluate the effectiveness of surgical interventions for Ménière's disease.
- Included all surgical modalities altering disease progression or abolishing vestibular function.
Main Methods:
- Conducted a systematic review of randomized or quasi-randomized controlled trials.
- Searched multiple databases including Cochrane, PubMed, EMBASE, and Web of Science up to February 2009.
- Two authors independently assessed trial quality and extracted data.
Main Results:
- Only endolymphatic sac surgery was assessed in two randomized trials (59 patients).
- Comparisons included ventilation tubes and simple mastoidectomy.
- No beneficial effect of endolymphatic sac surgery was reported versus placebo or grommet insertion.
Conclusions:
- Current evidence from two trials is insufficient to support the efficacy of endolymphatic sac surgery for Ménière's disease.
- Further high-quality research is needed to establish effective surgical treatments.
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