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Nutritional support for acute kidney injury.
1Department of Nephrology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan, China, 610041.
The Cochrane Database of Systematic Reviews
|January 22, 2010
Summary
Nutritional support for acute kidney injury (AKI) shows mixed results. While intravenous essential L-amino acids improved recovery and survival in some cases, overall evidence for nutritional interventions remains insufficient, necessitating further research.
Area of Science:
- Nephrology
- Critical Care Medicine
- Clinical Nutrition
Background:
- Acute kidney injury (AKI) management focuses on treating the cause and supporting recovery.
- Enteral and parenteral nutrition are used for AKI patients, but their effectiveness is debated.
Purpose of the Study:
- To evaluate the effectiveness and safety of nutritional support in patients with acute kidney injury.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) from multiple databases.
- Data extraction and quality assessment by independent reviewers.
- Results reported as risk ratios (RR) or mean differences (MD) with 95% confidence intervals (CI).
Main Results:
- Intravenous essential L-amino acids (EAA) showed increased AKI recovery rates and survival in dialyzed patients compared to glucose alone.
- Higher calorie total parenteral nutrition (TPN) did not improve nitrogen balance but increased triglycerides and glucose.
- Mixed results were observed for different amino acid formulations and nitrogen intake levels regarding nitrogen balance and urea metabolism.
Conclusions:
- Current evidence is insufficient to support the effectiveness of nutritional support for AKI.
- High-quality studies are needed to establish the efficacy and safety of nutritional interventions in AKI patients.
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