[Systemic components of pathogenesis of lower-limb atherosclerotic gangrene]

A prospective controlled study was carried out in a total of thirty-four patients presenting with atherosclerotic gangrene ofthe lower extremities. Surgery was preceded by studying haemostasiograms, biochemical parameters and indices of the functional system of detoxication, level of acute-phase proteins, cytokines, stress enzymes. It was determined that irreversibility of tissue damage in atherosclerotic gangrene of the lower limbs results in the development of the main pathogenetic phenomena of systemic impairments, i.e., stress reactions of the neuroendocrine system, systemic inflammatory response, activation of intravascular blood microcoagulation, oxidative stress, crash-like syndrome, autogenous intoxication, latent organic dysfunctions, forming in the aggregate a pathogenetically vicious circle of impairments with local manifestations, pain reaction, and various critical complications of this nosological entity.