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Updated: Jun 16, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Fibroblast growth factor signalling: from development to cancer
Nicholas Turner1, Richard Grose
1Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK, and Royal Marsden Hospital, London SW3 6JJ, UK. Nicholas.turner@icr.ac.uk
Fibroblast growth factors (FGFs) and their receptors are crucial for cell functions. Targeting FGF signaling in cancer is a developing therapeutic strategy, with potential for both tumor promotion and protection.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Fibroblast growth factors (FGFs) and their receptors regulate critical cellular processes like proliferation, survival, migration, and differentiation.
- Targeting FGF signaling pathways has historically lagged behind other receptor tyrosine kinases in cancer therapy development.
- Emerging evidence highlights the significant role of FGF signaling in the pathogenesis of various tumor types.
Purpose of the Study:
- To review the current understanding of FGF signaling in cancer.
- To discuss the development of clinical reagents targeting FGFs and their receptors.
- To explore the dual role of FGF signaling in tumorigenesis and tumor protection.
Main Methods:
- Literature review of studies on FGF signaling in cancer.
- Analysis of clinical trial data for FGF-targeted therapies.
- Examination of preclinical research on FGF signaling mechanisms in different cancer contexts.
Main Results:
- Substantial evidence supports the involvement of FGF signaling in diverse tumor types.
- Clinical reagents targeting FGFs and FGF receptors are under active development.
- FGF signaling can exhibit context-dependent roles, promoting tumorigenesis or mediating tumor protection.
Conclusions:
- FGF signaling is a critical pathway in cancer pathogenesis.
- Targeting FGF signaling represents a promising therapeutic avenue.
- Understanding the differential effects of FGF signaling is key for optimizing therapeutic strategies.
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