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Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
Published on: May 25, 2018
[Primary biphasic synovial sarcoma of the kidney]
F Wezel1, P Ströbel, H Michaely
1Urologische Klinik, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim. felix.wezel@umm.de
Der Urologe. Ausg. A
|January 23, 2010
Summary
Primary renal synovial sarcoma is a rare kidney tumor. This case highlights its identification via fluorescence in situ hybridization (FISH) in a patient with a large renal mass and caval thrombus.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Primary synovial sarcoma of the kidney is an exceptionally rare neoplasm, first identified in 2000.
- Renal masses can present diagnostic challenges, necessitating advanced characterization techniques.
Observation:
- A 47-year-old male presented with a large renal mass (11.7 x 9.3 x 8.1 cm) and an associated caval thrombus.
- The tumor was histologically classified as a biphasic differentiated spindle cell tumor.
Findings:
- Fluorescence in situ hybridization (FISH) confirmed the specific translocation t(X;18), which is characteristic of synovial sarcoma.
- The findings support the classification of the renal mass as a primary synovial sarcoma.
Implications:
- Synovial sarcoma should be considered in the differential diagnosis of renal tumors, particularly in younger patients with spindle cell-like presentations.
- Accurate diagnosis of rare renal neoplasms is crucial for appropriate treatment planning and patient management.
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