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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Multicenter prospective study analysing the role of rotavirus on acute gastroenteritis in Spain

F Gimenez-Sanchez1, A Delgado-Rubio1, F Martinon-Torres1

  • 1.Pediatric Infectious Diseases Unit, Hospital Torrecardenas, Almeria, Spain.Pediatrics Department, Hospital de Madrid, Madrid, Spain.Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.Hospital Virgen del Camino, Pamplona, Spain.

Acta Paediatrica (Oslo, Norway : 1992)
|January 26, 2010
PubMed

Insights

Rotavirus is the leading cause of acute gastroenteritis (AGE) in young children in Spain, resulting in more severe symptoms and hospitalizations. Breastfeeding offers protection against rotavirus AGE.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Paediatric rotavirus gastroenteritis is a major global cause of acute gastroenteritis (AGE) in children under five.
  • Rotavirus is the most frequent cause of AGE in children up to 5 years of age worldwide.

Purpose of the Study:

  • To analyze the clinical characteristics of AGE caused by rotavirus.
  • Compare rotavirus AGE with AGE caused by other agents.

Main Methods:

  • Study conducted in 30 Spanish health-care centers (25 hospitals, 5 primary centers) from January to March 2006.
  • Included children up to 2 years of age with AGE.
  • Stool samples analyzed via immunochromatographic test for rotavirus; clinical and epidemiological data collected.

Main Results:

  • 1192 children enrolled (mean age 11.2 months).
  • Rotavirus-positive AGE cases showed higher frequency of fever, vomiting, weakness, and dehydration.
  • Higher severity scores and increased likelihood of hospitalization observed in rotavirus AGE. Family history of AGE was more common in rotavirus cases. Breastfeeding demonstrated a protective effect.

Conclusions:

  • Rotavirus is the primary cause of AGE in children under 2 in Spain, leading to more severe symptoms and hospital admissions than other agents.
  • Findings support the inclusion of rotavirus vaccines in the Spanish immunization schedule.
Abstract

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