Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complications and factors associated with emergency department presentation for pediatric tracheostomy patients.

International journal of pediatric otorhinolaryngology·2026
Same author

Employing a multidisciplinary tracheostomy team to improve the care process of pediatric patients.

International journal of pediatric otorhinolaryngology·2025
Same author

Moral distress in Pediatric otolaryngology: A survey of ASPO members.

International journal of pediatric otorhinolaryngology·2025
Same author

Effects of Inhaled Dexamethasone/Ciprofloxacin on Acute Subglottic Stenosis in a Rabbit Model.

Laryngoscope investigative otolaryngology·2025
Same author

Multi-institutional Validation of the Interarytenoid Assessment Protocol for Pediatric Laryngeal Cleft.

The Laryngoscope·2024
Same author

Patient factors associated with positive respiratory cultures following tracheostomy in pediatric patients.

International journal of pediatric otorhinolaryngology·2024
Same journal

Otovent Versus Valsalva: Physiological Insights for Diagnostic and Therapeutic Autoinflation in Eustachian Tube Dysfunction.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

CSNK1A1 Mediates Inner Ear Inflammation and Endolymphatic Hydrops in a Lipopolysaccharide-Induced Mouse Model.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Medial Flap Versus Coblation-Assisted Turbinoplasty For Turbinates Hypertrophy: A Prospective Randomized Controlled Trial.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Gender-Affirming Care in Otolaryngology: A State of the Art Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Caffeine Consumption and Rhinologic Symptom Severity.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Ethical Considerations in Using the Pernkopf Atlas in Otolaryngology Education Ethics in Practice: Point-Counterpoint.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Olfactory changes after endoscopic pituitary tumor resection.

Catherine K Hart1, Phillip V Theodosopoulos, Lee A Zimmer

  • 1Department of Otolaryngology, Head and Neck Surgery, The University of Cincinnati Neuroscience Institute, Cincinnati, OH, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|January 26, 2010
PubMed
Summary
This summary is machine-generated.

Transnasal endoscopic surgery for pituitary masses causes a temporary decline in smell, but olfactory function returns to normal within three months. This surgical approach has no lasting impact on a patient's sense of smell.

More Related Videos

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jun 16, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Area of Science:

  • Otolaryngology
  • Neurosurgery
  • Endocrinology

Background:

  • Transnasal endoscopic surgery is a common approach for pituitary adenomas.
  • This surgical technique involves resecting anatomical regions containing olfactory neuroepithelium.
  • The potential impact on olfaction requires careful evaluation.

Purpose of the Study:

  • To assess the effect of transnasal endoscopic surgery on olfactory function.
  • To determine if olfactory deficits are transient or persistent after surgery.
  • To evaluate the clinical significance of olfactory changes post-surgery.

Main Methods:

  • A case series design was employed with planned data collection.
  • Adult patients with pituitary masses underwent olfactory testing using the University of Pennsylvania Smell Identification Test (UPSIT) before and after surgery.
  • Olfactory function was reassessed at one and three months postoperatively, with statistical analysis using paired Student t tests.

Main Results:

  • 57 patients were enrolled; 50 completed one-month and 45 completed three-month follow-up.
  • Average UPSIT scores were 31.8 preoperatively, 30.5 at one month, and 32.6 at three months.
  • A statistically significant decrease in olfactory scores was observed at one month (P = 0.01), but not at three months (P = 0.08).

Conclusions:

  • Transnasal endoscopic surgery for pituitary masses results in a transient, not clinically significant, decline in olfactory function.
  • Olfactory function recovers by three months post-surgery.
  • The surgical approach has no long-term adverse effect on olfaction despite the removal of olfactory structures.