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Bringing the Clinic Home: An At-Home Multi-Modal Data Collection Ecosystem to Support Adaptive Deep Brain Stimulation

Bringing the Clinic Home: An At-Home Multi-Modal Data Collection Ecosystem to Support Adaptive Deep Brain Stimulation

Published on: July 14, 2023

Update on deep brain stimulation for neuropsychiatric disorders.

Herbert E Ward¹, Nelson Hwynn, Michael S Okun

¹University of Florida Department of Psychiatry, McKnight Brain Institute, Movement Disorders Center, PO Box 100283, Gainesville, FL 32610-0383, USA. hward@ufl.edu <hward@ufl.edu>

Neurobiology of Disease

|January 26, 2010

Summary

Deep brain stimulation (DBS) offers hope for severe depression, OCD, and Tourette's syndrome. Careful patient selection and research protocols are crucial for optimizing this neuromodulation therapy.

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Area of Science:

Neuroscience
Neurology
Psychiatry

Background:

Deep brain stimulation (DBS) is effective for medication-refractory movement disorders.
Preliminary studies explore DBS for severe, treatment-resistant depression, OCD, and Tourette's syndrome.

Purpose of the Study:

To review the current state of DBS in neuropsychiatric disorders.
To discuss pathophysiology, patient selection, and brain targets for depression, OCD, and TS.

Main Methods:

Review of existing literature on DBS for depression, OCD, and TS.
Analysis of pathophysiological and imaging studies related to basal ganglia circuitry.
Examination of clinical observations and research protocols.

Main Results:

DBS shows promise for severe neuropsychiatric conditions, but requires cautious application.
Understanding basal ganglia circuitry is key to identifying effective neuromodulation targets.
Interdisciplinary and ethical screening is essential for treatment candidacy.

Conclusions:

A cautious, research-driven approach is needed for DBS in depression, OCD, and TS.
Patient selection and brain targets must be disorder- and symptom-specific.
Further research is vital to refine DBS protocols and optimize outcomes.