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Hypocitraturia and hyperoxaluria after Roux-en-Y gastric bypass surgery
Naim M Maalouf1, Prasanthi Tondapu, Eve S Guth
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. naim.maalouf@utsouthwestern.edu
The Journal of Urology
|January 26, 2010
Summary
Roux-en-Y gastric bypass patients show higher rates of hyperoxaluria and hypocitraturia, increasing kidney stone risk. Lower urine calcium in these patients may mitigate this risk, despite obesity being a common factor.
Area of Science:
- Nephrology
- Bariatric Surgery
- Metabolic Disorders
Background:
- Obesity is a known risk factor for kidney stones.
- Roux-en-Y gastric bypass (RYGB) surgery is linked to increased nephrolithiasis risk.
- Understanding the mechanisms behind RYGB-associated kidney stones is crucial.
Purpose of the Study:
- To investigate the urinary tract stone risk profiles in patients post-RYGB compared to obese individuals without a history of stones.
- To identify specific urinary biochemical changes predisposing to nephrolithiasis after RYGB.
Main Methods:
- Cross-sectional study comparing 19 non-stone forming RYGB patients with 19 matched obese controls.
- Evaluation of urine and serum biochemistry in both groups.
Main Results:
- RYGB patients exhibited significantly higher urine oxalate and lower urine citrate levels compared to controls.
- The prevalence of hyperoxaluria and hypocitraturia was significantly elevated in RYGB patients.
- RYGB patients showed significantly lower urine calcium excretion than obese controls.
Conclusions:
- Nearly half of RYGB patients without prior kidney stones displayed hyperoxaluria or hypocitraturia.
- These stone risk factors are significantly more prevalent in RYGB patients than in matched obese controls.
- Reduced urine calcium excretion in RYGB patients may counteract the increased risk of stone formation.
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