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Related Experiment Video

Updated: Jun 16, 2026

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
10:36

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

Cortical depression in the mouse auditory cortex after sound discrimination learning.

Shinsuke Ohshima1, Hiroaki Tsukano, Yamato Kubota

  • 1Department of Neurophysiology, Brain Research Institute, Niigata University, 1 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan.

Neuroscience Research
|January 26, 2010
PubMed
Summary

Mice learned to distinguish sounds, showing reduced brain responses to ignored sounds (S-) in the auditory cortex. This learning-specific depression was prominent for complex frequency-modulated sounds.

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Published on: October 22, 2015

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Sensory Processing

Background:

  • Sound discrimination learning is crucial for survival.
  • Understanding neural plasticity in the auditory cortex provides insights into learning and memory.
  • Previous research has explored auditory cortex plasticity, but specific mechanisms for discriminating complex sounds remain unclear.

Purpose of the Study:

  • To investigate cortical responses following sound discrimination learning in mice.
  • To determine how the auditory cortex processes rewarded (S+) versus unrewarded (S-) sound stimuli after learning.
  • To identify specific sound features that elicit changes in cortical activity post-learning.

Main Methods:

  • Utilized transcranial flavoprotein fluorescence imaging in anesthetized mice.
  • Trained water-deprived mice to discriminate between rewarded and unrewarded auditory stimuli.
  • Recorded cortical responses in the right auditory cortex to pure tones (PT) and amplitude-modulated (AM) sounds, and frequency-modulated (FM) sounds.

Main Results:

  • Cortical responses to unrewarded amplitude-modulated (AM) sounds were significantly depressed after learning, unlike pure tone (PT) stimuli.
  • Responses to unrewarded frequency-modulated (FM) sounds (upward and downward) were also significantly depressed.
  • No significant changes were observed in responses to rewarded stimuli (S+) or in the left auditory cortex.
  • Learning-induced depression of FM sound responses was localized to the medial part of the tonotopic band for 40 kHz in the primary auditory cortex.

Conclusions:

  • Sound discrimination learning induces specific neural plasticity in the auditory cortex.
  • The auditory cortex exhibits differential processing of unrewarded complex sounds (AM and FM) compared to pure tones.
  • The medial tonotopic band associated with 40 kHz in the primary auditory cortex may play a role in processing frequency-modulated sounds.