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Updated: Jun 16, 2026

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
Critical parameters in a supported liquid membrane extraction technique for ionizable organic compounds with a
Luke Chimuka1, Titus A M Msagati, Ewa Cukrowska
1School of Chemistry, University of the Witwatersrand, P/Bag 3, Wits, 2050 Johannesburg, South Africa. luke.chimuka@wits.ac.za
Abstract:
The reviews cover important critical parameters that are often optimized in a supported liquid membrane extraction technique in both flat sheet and hollow fibre designs for ionizable organic molecules. Understanding of these parameters can enable one to predict the behavior of the compound before hand and thus reduce the number of optimization experiments. Moreover, less number of experiments can be also generated using statistical techniques which are now becoming more commonly used. Supported liquid membrane extraction optimal parameters such as the conditions of the pH of the acceptor and donor phases should easily be fixed from the pKa values of the compounds. Other parameters, including the polarity of the compound can help to predict the partitioning into the membrane and the behavior of the compound. The influence of parameters such as temperature on the mass transfer in supported liquid membrane depends on the design of the module, experimental design and type of mass transfer controlling the extraction process.
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