Related Experiment Video

Updated: Jun 16, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Effects of adeno-tonsillectomy on polysomnography patterns in Down syndrome children with obstructive sleep apnea: a

Mona M Shete1, Rose Mary S Stocks, Merry E Sebelik

  • 1Otolaryngology & Head and Neck Surgery, University Tennessee Health Science Center, 910 Madison Ave, Suite 429, Memphis, TN 38163, USA. mshete@utmem.edu

International Journal of Pediatric Otorhinolaryngology
|January 26, 2010
PubMed

Insights

Adeno-tonsillectomy (T&A) improves some breathing issues in children with Down syndrome (DS) and obstructive sleep apnea (OSA), but less effectively than in non-DS children. Many DS children still require further treatment after T&A.

Area of Science:

  • Pediatric Sleep Medicine
  • Genetics and Sleep Disorders
  • Otolaryngology

Background:

  • Obstructive sleep apnea (OSA) is common in children with Down syndrome (DS).
  • Adeno-tonsillectomy (T&A) is a primary treatment for OSA in children.
  • The effectiveness of T&A in DS children with OSA is not fully understood.

Purpose of the Study:

  • To evaluate the impact of T&A on breathing and sleep parameters in children with DS and OSA.
  • To compare the outcomes of T&A in DS children with those of non-DS children suffering from OSA.

Main Methods:

  • Retrospective chart review of pediatric sleep center data.
  • Analysis of polysomnography (PSG) data from 11 DS and 9 non-DS children before and after T&A.
  • Comparison of pre- and post-T&A PSG parameters using statistical tests.

Main Results:

  • T&A led to significant improvement in total apnea-hypopnea index (AHI) in both groups, but the improvement was less pronounced in the DS group.
  • No significant changes were observed in REM-AHI or lowest SaO2 in the DS group post-T&A.
  • While both groups showed mild sleep parameter improvements, 73% of DS children still required further OSA treatment (CPAP, BiPAP, or oxygen).

Conclusions:

  • T&A offers partial improvement for OSA in children with DS.
  • The effectiveness of T&A for OSA is notably less significant in DS children compared to their non-DS counterparts.
  • Ongoing management is frequently necessary for persistent OSA in DS children post-T&A.
Abstract

More Related Videos

Acupoint Application Combined with Ear Plaster Therapy for Treating Sleep Disorders with Acute Exacerbation of Chronic Obstructive Pulmonary Disease04:53

Acupoint Application Combined with Ear Plaster Therapy for Treating Sleep Disorders with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Published on: October 18, 2024

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Narcolepsy01:07

Narcolepsy

Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.