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Related Experiment Video

Updated: Jun 16, 2026

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Subcortical alignment precision in patients with schizophrenia.

Alan Anticevic1, Grega Repovs, Jared X Van Snellenberg

  • 1Department of Psychology, Washington University in St. Louis, MO 63130, USA. aanticev@artsci.wustl.edu

Schizophrenia Research
|January 26, 2010
PubMed
Summary

Schizophrenia patients show accurate alignment of subcortical brain structures, unlike cortical areas. This finding suggests subcortical alignment is unlikely to confound functional neuroimaging studies comparing schizophrenia patients and controls.

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Published on: November 27, 2019

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Medical Image Analysis

Background:

  • Previous research indicates compromised cortical structure alignment in schizophrenia patients compared to controls.
  • This cortical misalignment may confound functional neuroimaging studies comparing patient and control groups.
  • The alignment precision of subcortical structures in schizophrenia remains uninvestigated.

Purpose of the Study:

  • To investigate the alignment precision of major subcortical structures in patients with schizophrenia.
  • To determine if subcortical structure alignment differs between schizophrenia patients and control subjects.
  • To assess the potential confounding effect of subcortical alignment on neuroimaging research.

Main Methods:

  • Utilized validated methods for assessing cortical alignment precision.
  • Examined alignment precision for key subcortical structures: amygdala, caudate, hippocampus, pallidum, putamen, and thalamus.
  • Compared alignment precision between schizophrenia patients (N=48) and control subjects (N=45) using different templates.

Main Results:

  • Major subcortical structures demonstrated similar alignment precision in both schizophrenia patients and control subjects.
  • Alignment precision was consistent regardless of the template used (schizophrenia or healthy controls).
  • This contrasts with previously reported findings for cortical structures.

Conclusions:

  • Subcortical structure alignment is not compromised in patients with schizophrenia.
  • Accurate subcortical alignment is unlikely to confound between-group functional neuroimaging investigations in schizophrenia research.
  • Findings support the reliable use of subcortical neuroimaging data for schizophrenia studies.