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Updated: Jun 16, 2026

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
Published on: January 10, 2015
The globalization of tobacco use: 21 challenges for the 21st century
Thomas Glynn1, John R Seffrin, Otis W Brawley
1International Cancer Control, American Cancer Society, Washington, DC 20004, USA. tom.glynn@cancer.org
Abstract:
The globalization of tobacco began more than 500 years ago, but the public health response to the death, disease, and economic disruption that it has caused is fewer than 50 years old. In this report, the authors briefly trace the history of tobacco use and commerce as it moved from the Americas in the late 15th century and then eastward. They then discuss the wide range of issues that must be addressed, and the equally wide range of expertise that is needed if the global health community is to be successful in reducing, and eventually eliminating, the rising tide of tobacco use, particularly in the low- and middle-income nations that are the target of the multinational tobacco industry.
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