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Related Experiment Video

Updated: Jun 16, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
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Tunable plasmonic nanobubbles for cell theranostics.

E Y Lukianova-Hleb1, E Y Hanna, J H Hafner

  • 1Laboratory for Laser Cytotechnologies, A V Lykov Heat and Mass Transfer Institute, 15 Brovka Street, Minsk 220072, Belarus.

Nanotechnology
|January 26, 2010
PubMed
Summary
This summary is machine-generated.

Researchers developed plasmonic nanobubbles (PNB) for cellular theranostics. These gold nanoparticle-generated bubbles enable non-invasive imaging and targeted cell disruption, acting as tunable agents for diagnosis and therapy.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cell Biology

Background:

  • Theranostics, combining diagnosis and therapy, requires improved cellular selectivity.
  • Current methods lack efficient agents for targeted cellular-level theranostics.

Purpose of the Study:

  • To develop a novel method for cellular-level theranostics using gold nanoparticle-generated nanobubbles.
  • To demonstrate tunable diagnostic and therapeutic capabilities of plasmonic nanobubbles (PNB).

Main Methods:

  • Developed plasmonic nanobubbles (PNB) from gold nanoparticles (NP).
  • Delivered NPs to target cells and induced intracellular PNBs using laser fluence.
  • Tuned PNB action for imaging (low fluence) and cell disruption (high fluence).

Main Results:

  • Achieved a 50-fold non-invasive amplification of optical scattering amplitude using PNBs.
  • Demonstrated selective mechanical damage to specific cells via PNBs.
  • Enabled optical guidance of therapy through bubble-specific signals.

Conclusions:

  • PNBs function as tunable theranostic agents at the cellular level.
  • The PNB method integrates diagnosis, therapy, and guidance in a single process.
  • This approach offers significant benefits for research and disease systems requiring cellular-level intervention.