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Updated: May 14, 2026

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Published on: March 23, 2021
Experimental techniques for imaging and measuring transient vapor nanobubbles
E Y Lukianova-Hleb1, D O Lapotko
1Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005, USA.
Abstract:
Imaging and measuring transient vapor bubbles at nanoscale pose certain experimental challenges due to their reduced dimensions and lifetimes, especially in a single event experiment. Here, we analyze three techniques that employ optical scattering and acoustic detection in identifying and quantifying individual photothermally induced vapor nanobubbles (NBs) at a wide range of excitation energies. In optically transparent media, the best quantitative detection can be achieved by measuring the duration of the optical scattering time-response, while in an opaque media, the amplitude of the acoustic time-response well describes NBs in the absence of stress waves.
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