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Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Cholesterol: Significance and Regulation01:29

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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
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Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Lipid-derived Compounds in the Human Body01:31

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Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
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Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
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Fats as Energy Storage Molecules01:06

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Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...

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Related Experiment Video

Updated: Jun 16, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Inflammatory lipid mediators in adipocyte function and obesity.

Abishek Iyer1, David P Fairlie, Johannes B Prins

  • 1School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

Nature Reviews. Endocrinology
|January 26, 2010
PubMed
Summary

Lipid mediators may drive obesity-related inflammation by activating immune receptors. This low-grade inflammation disrupts adipocyte function and metabolic homeostasis, contributing to metabolic dysfunction.

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Isolation of Adipose Tissue Immune Cells
07:09

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Published on: May 22, 2013

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Last Updated: Jun 16, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

Area of Science:

  • Immunology
  • Metabolic Science
  • Cell Biology

Background:

  • Multicellular organism survival relies on immune and metabolic functions.
  • Obesity involves complex interactions between immunoinflammatory cells and adipocytes.
  • Understanding factors regulating immune and adipocyte function is crucial for metabolic homeostasis.

Purpose of the Study:

  • To explore the role of lipid mediators in obesity-associated inflammation.
  • To investigate how lipid mediators influence adipocyte and immune cell function.
  • To propose a paradigm linking lipid mediators, inflammation, and metabolic dysfunction.

Main Methods:

  • Literature review and synthesis of current research on lipid mediators and obesity.
  • Analysis of signaling pathways involving lipid mediators, immune receptors, and adipocytes.
  • Speculative model development based on existing evidence.

Main Results:

  • Chronic lipid overload in obesity can induce cellular stress and inflammation.
  • Lipid mediators bind to immune receptors (e.g., G-protein-coupled receptors, Toll-like receptors).
  • Disruption of lipid mediator regulation can initiate disease processes.

Conclusions:

  • Lipid mediators are implicated in low-grade tissue inflammation.
  • This inflammation contributes to adipocyte dysfunction and metabolic disorders.
  • Further research into lipid mediator-immune receptor interactions is warranted for obesity and metabolic dysfunction.