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[Evolution of kidney function and progression factors in nephrectomised patients]
I Juan1, M J Puchades, M A Solís
1Servicio de Nefrología, Hospital Clínico Universitario de Valencia. ijuangar@hotmail.com
Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|January 26, 2010
Summary
Nephrectomized patients with pre-existing reduced kidney function (FG < 60 ml/min) show slower progression to chronic kidney disease. However, proteinuria indicates a higher risk of renal failure in these one-kidney patients.
Area of Science:
- Nephrology
- Urology
- Internal Medicine
Context:
- Retrospective observational study of 92 one-kidney surgical patients.
- Patients evaluated in Nephrology surgery at a University Clinic Hospital.
- Average age 67 years, with a post-surgery monitoring period of 21 years.
Purpose:
- To assess the variability in outcomes for nephrectomized patients.
- To evaluate renal function evolution in patients with one kidney.
- To compare outcomes based on pre-surgery glomerular filtration (FG) levels.
Summary:
- Patients were divided into two groups: Group 1 (FG < 60 ml/min) and Group 2 (FG > 60 ml/min).
- Group 1 (24 patients) showed lower average FG (48 ml/min), higher incidence of proteinuria (8%), and hypertension (63%). 21% progressed to advanced chronic kidney disease (E4/E5), with 5 requiring renal replacement therapy.
- Group 2 (68 patients) had higher average FG (76.5 ml/min), lower proteinuria (10%), and hypertension (34%). 80% reached E3 stage, with slower progression and better long-term renal function preservation.
Impact:
- Suggests that monorrenal surgical patients generally exhibit slow progression of renal disease.
- Highlights emerging proteinuria as a significant indicator of progressive chronic kidney disease in these patients.
- Provides insights into long-term renal function outcomes and risk factors in post-nephrectomy populations.
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