Related Experiment Video

Updated: Jun 16, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

Linking soluble vascular adhesion molecule-1 level to calcific aortic stenosis in patients with coronary artery

Katerina Linhartova1, Gabriela Sterbakova, Jaroslav Racek

  • 1Department of Cardiology, Cardiovascular Center, Motol University Hospital;

Experimental and Clinical Cardiology
|January 26, 2010
PubMed

Insights

Elevated soluble vascular adhesion molecule-1 (s-VCAM-1) levels are linked to calcific aortic stenosis (AS) in patients with coronary artery disease (CAD). Lower soluble intercellular adhesion molecule-1 (s-ICAM-1) was also associated with AS.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Atherosclerosis Research

Background:

  • Calcific aortic stenosis (AS) is a prevalent valve disease linked to atherosclerosis, often necessitating surgical intervention.
  • Understanding the role of inflammation in AS pathogenesis is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the association between specific inflammatory markers and the presence of AS in patients with advanced coronary artery disease (CAD).
  • To identify potential biomarkers for calcific AS in the context of atherosclerosis.

Main Methods:

  • Prospective study enrolling patients with CAD and AS (gradient ≥30 mmHg) and controls with aortic sclerosis (gradient ≤10 mmHg).
  • Clinical evaluation, echocardiography, and coronary angiography were performed on all participants.
  • Levels of soluble adhesion molecules (s-VCAM-1, s-ICAM-1, s-E-selectin) and C-reactive protein were measured.

Main Results:

  • Patients with AS were older and exhibited significantly higher levels of s-VCAM-1 compared to controls.
  • AS patients showed lower levels of s-ICAM-1 and s-E-selectin.
  • C-reactive protein levels did not differ significantly between the groups.
  • Elevated s-VCAM-1 and reduced s-ICAM-1 were independently associated with AS after adjusting for age.

Conclusions:

  • Increased s-VCAM-1 levels are significantly associated with calcific aortic stenosis in patients with substantial coronary artery disease.
  • Adhesion molecule profiles may serve as indicators for AS in atherosclerotic populations.
Abstract

Keywords:
Adhesion moleculesAortic stenosisCalcificationVCAM-1

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...