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Related Experiment Video

Updated: Jun 16, 2026

Knee Arthrocentesis in Adults
04:41

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Published on: February 25, 2022

Local effects of intra-articular corticosteroids.

George S Habib1, Walid Saliba, Munir Nashashibi

  • 1Department of Medicine, Carmel Medical Center, Faculty of Medicine, Technion, Haifa, Israel. gshabib62@yahoo.com

Clinical Rheumatology
|January 27, 2010
PubMed
Summary
This summary is machine-generated.

Intra-articular corticosteroid injections (IACIs) offer pain relief, particularly for inflammatory conditions like juvenile idiopathic arthritis. While generally safe, potential local adverse effects exist but are typically rare or insignificant.

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Area of Science:

  • Rheumatology
  • Orthopedics
  • Pharmacology

Background:

  • Intra-articular corticosteroid injections (IACIs) are frequently utilized for joint pain management.
  • Understanding the localized effects of IACIs is crucial for optimizing treatment and patient outcomes.

Purpose of the Study:

  • To comprehensively review the published literature on the local effects of intra-articular corticosteroid injections.
  • To document both beneficial and adverse local effects across various joint conditions.

Main Methods:

  • Systematic English literature search on PubMed using terms 'intra-articular' and 'local effect'.
  • Inclusion of studies examining subjective, functional, structural, cellular, humoral, molecular, and imaging aspects.
  • Documentation of all reported local adverse effects.

Main Results:

  • The primary benefit of IACI is pain relief, with variable duration dependent on disease type and severity.
  • Favorable responses are more pronounced in inflammatory conditions, such as juvenile idiopathic arthritis, with longer remission periods.
  • No significant joint structural damage (e.g., joint space loss, cartilage erosion) was observed following multiple or single IACIs in osteoarthritis and rheumatoid arthritis, respectively.

Conclusions:

  • Intra-articular corticosteroid injections demonstrate a wide spectrum of local effects, with prominent subjective and functional improvements in inflammatory arthritis.
  • While generally safe, potential local adverse effects like calcifications and atrophy can occur but are infrequent.
  • Image-guided IACIs may enhance treatment efficacy in specific joints.