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  1. Home
  3. Sars-cov-2 Infection, Vaccination Status, And Dementia Risk: A Nested Case-control Study.
  1. Home
  3. Sars-cov-2 Infection, Vaccination Status, And Dementia Risk: A Nested Case-control Study.

Related Experiment Video

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

SARS-CoV-2 Infection, Vaccination Status, and Dementia Risk: A Nested Case-Control Study.

Nika Zur1,2, Nili Stein3,4, Walid Saliba4,5,6

  • 1School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.

Influenza and Other Respiratory Viruses
|June 20, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

COVID-19 infection increases dementia risk, particularly in hospitalized patients. Vaccination offers protection, with risk comparable to other respiratory infections like pneumonia.

Keywords:
COVID‐19 severitypneumoniavaccination

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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Cognitive impairment following SARS-CoV-2 infection is a growing concern.
  • Existing research on the link between COVID-19 and dementia risk is inconsistent.
  • Understanding this association is crucial for public health strategies.

Purpose of the Study:

  • To investigate the association between SARS-CoV-2 infection and incident dementia risk.
  • To explore the impact of COVID-19 vaccination on dementia risk.
  • To compare dementia risk after SARS-CoV-2 infection with that of pneumonia.

Main Methods:

  • A nationwide nested case-control study in Israel involving individuals aged 50+.
  • Matched 27,280 dementia cases with 272,800 dementia-free controls using density sampling.
  • Analyzed associations using multivariable conditional logistic regression models.

    • Main Results:

    • SARS-CoV-2 infection was linked to a higher dementia risk (OR=1.18), especially in hospitalized patients.
    • The risk was comparable to pneumonia (OR=1.89) and diminished after six months.
    • COVID-19 vaccination correlated with reduced dementia risk (7-31% lower with 2-4 doses).

    Conclusions:

    • COVID-19 infection, particularly severe cases requiring hospitalization, is associated with increased dementia diagnoses.
    • The dementia risk following COVID-19 is comparable to that of other respiratory infections.
    • COVID-19 vaccination demonstrates a protective effect against dementia.