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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Updated: Jun 16, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Hypertrophic cardiomyopathy in the elderly.

Toru Kubo¹, Hiroaki Kitaoka, Makoto Okawa

¹Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan.

Geriatrics & Gerontology International

|January 28, 2010

Summary

Hypertrophic cardiomyopathy (HCM) often affects elderly patients, not just the young. This study details HCM

Area of Science:

Cardiology
Genetics
Geriatrics

Background:

Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder with varied presentations.
While often associated with young individuals, HCM increasingly affects elderly populations.
Limited research exists on the specific clinical features of HCM in older adults.

Purpose of the Study:

To describe the clinical characteristics of hypertrophic cardiomyopathy in a community-based elderly cohort.
To investigate the prevalence and features of HCM in an aged population in Japan.

Main Methods:

Established a cardiomyopathy registration study in Kochi Prefecture, a region with a high elderly population.
Analyzed clinical, morphological, and functional data from a community-based HCM cohort.

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Last Updated: Jun 16, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Focused on patients aged 60 years and above, who comprised 70% of the cohort.

Main Results:

The majority of the registered HCM patients were elderly (70% aged >=60).
Late-onset HCM is often linked to genetic mutations, particularly in the cardiac myosin-binding protein C gene.
Elderly HCM patients experienced significant heart failure and embolic events, strongly associated with atrial fibrillation.

Conclusions:

Hypertrophic cardiomyopathy is prevalent in the elderly, often with genetic underpinnings.
Heart failure and embolic events are critical complications in middle-aged and elderly HCM patients.
Longitudinal management is crucial for preventing adverse clinical outcomes in HCM.