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Heritability of exocrine pancreatic insufficiency in German Shepherd dogs

E Westermarck¹, S A M Saari, M E Wiberg

¹Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014 Helsinki, Finland. elias.westermarck@helsinki.fi

Journal of Veterinary Internal Medicine

|January 28, 2010

Abstract

Background:

Several studies have revealed that exocrine pancreatic insufficiency (EPI) is an inherited disease in German Shepherd Dogs (GSDs). Pedigree analyses have suggested an autosomal recessive inheritance model.

Objective:

Test mating of 2 dogs with EPI.

Animals:

A sire and dam purebred GSD both with EPI and a litter of 6 puppies.

Methods:

Test mating and long-term follow-up of offspring. The pancreas was biopsied via laparotomy on 26 occasions. Serum trypsin-like immunoreactivity was measured. Study was approved by Animal Ethics Committee.

Results:

During the 12-year study period only 2 of the 6 offsprings developed pancreatic acinar atrophy (PAA). In 1 puppy, end-stage PAA and in the other puppy partial PAA was diagnosed.

Conclusions And Clinical Importance:

PAA is not a congenital disease in GSDs. This study provided evidence that PAA is not inherited in a simple autosomal recessive fashion.

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