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Technical challenges associated with the radiolabeling of monoclonal antibodies utilizing short-lived, positron
1Department of Medical Imaging, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1991
Abstract:
Many factors, both physical and chemical, affect the radiolabeling of a chemical compound. These factors add a new dimension of complexity when the labeling of monoclonal antibodies is attempted with short-lived, positron emitting radionuclides. A lack of appreciation for the unique chemical separations associated with the radionuclide incorporated into the synthetic precursor can often lead to unexpected or non-reproducible results.