Related Experiment Video

Updated: Jun 16, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
08:36

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

Nuclear factor-kappaB and tumor-associated macrophages

Alessandra Mancino1, Toby Lawrence

  • 1Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, Marseille, France.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|January 28, 2010
PubMed

Insights

Tumor-associated macrophages (TAM) promote cancer progression. Targeting the Nuclear factor-kappaB (NF-kappaB) pathway in TAM offers a promising new strategy for cancer therapy.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Tumor-associated macrophages (TAM) are key players in cancer progression, promoting angiogenesis, growth, and metastasis.
  • The exact mechanisms sustaining the protumorigenic phenotype of TAM are not fully elucidated.
  • Signaling pathways regulating TAM phenotype and function are crucial for understanding cancer development.

Purpose of the Study:

  • To review the critical role of Nuclear factor-kappaB (NF-kappaB) in regulating TAM phenotype and function.
  • To explore the potential of targeting the NF-kappaB pathway as a novel cancer therapeutic strategy.

Main Methods:

  • Literature review focusing on genetic studies and signaling pathways.
  • Analysis of the role of NF-kappaB in integrating tumor microenvironment signals.
  • Examination of NF-kappaB's function in TAM-mediated carcinogenesis.

Main Results:

  • NF-kappaB is identified as a master regulator of inflammatory and immune responses.
  • Genetic studies highlight NF-kappaB's importance in TAM for processing pro-carcinogenic signals.
  • The NF-kappaB pathway is central to TAM's contribution to the tumor microenvironment.

Conclusions:

  • NF-kappaB plays a pivotal role in maintaining the protumorigenic functions of TAM.
  • Targeting the NF-kappaB pathway in TAM represents a potential novel therapeutic avenue for cancer treatment.

More Related Videos

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...