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Complement component C3 allotypes and outcomes in liver transplantation

Navdeep Dhillon1, Liron Walsh, Bernd Krüger

  • 1Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
|January 28, 2010
PubMed

Insights

Donor and recipient complement component C3 (C3) genotypes do not impact liver transplant outcomes, including ischemia-reperfusion injury and graft survival. This study found no significant association between C3 allotypes and patient results after liver transplantation.

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Genetics

Background:

  • The complement system plays a role in liver disease pathogenesis.
  • Human complement component C3 (C3) has two allotypes: fast (F) and slow (S).

Purpose of the Study:

  • To investigate the influence of C3 allotypes on liver transplant outcomes.
  • To determine the association between donor and recipient C3 genotypes and ischemia-reperfusion (IR) injury and graft survival.

Main Methods:

  • Analysis of 430 liver transplant recipients from 2000-2004.
  • Determination of C3 allotypes in 296 donor-recipient pairs.
  • Correlation of C3 genotypes with clinical outcomes, including IR injury and graft survival.

Main Results:

  • No significant difference in IR injury rates among the four C3 genotype groups (P = 0.16).
  • Hazard ratios for liver allograft survival showed no significant differences between the C3 SS donor/recipient group and other C3 genotype combinations.
  • Mean follow-up was 4.3 years.

Conclusions:

  • Donor and recipient C3 genotypes are not associated with liver transplantation outcomes.
  • C3 allotypes do not appear to be a predictive factor for IR injury or graft survival in liver transplant recipients.

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