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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Jun 16, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Complement component C3 allotypes and outcomes in liver transplantation.

Navdeep Dhillon1, Liron Walsh, Bernd Krüger

  • 1Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
|January 28, 2010
PubMed
Summary

Donor and recipient complement component C3 (C3) genotypes do not impact liver transplant outcomes, including ischemia-reperfusion injury and graft survival. This study found no significant association between C3 allotypes and patient results after liver transplantation.

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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

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Last Updated: Jun 16, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Genetics

Background:

  • The complement system plays a role in liver disease pathogenesis.
  • Human complement component C3 (C3) has two allotypes: fast (F) and slow (S).

Purpose of the Study:

  • To investigate the influence of C3 allotypes on liver transplant outcomes.
  • To determine the association between donor and recipient C3 genotypes and ischemia-reperfusion (IR) injury and graft survival.

Main Methods:

  • Analysis of 430 liver transplant recipients from 2000-2004.
  • Determination of C3 allotypes in 296 donor-recipient pairs.
  • Correlation of C3 genotypes with clinical outcomes, including IR injury and graft survival.

Main Results:

  • No significant difference in IR injury rates among the four C3 genotype groups (P = 0.16).
  • Hazard ratios for liver allograft survival showed no significant differences between the C3 SS donor/recipient group and other C3 genotype combinations.
  • Mean follow-up was 4.3 years.

Conclusions:

  • Donor and recipient C3 genotypes are not associated with liver transplantation outcomes.
  • C3 allotypes do not appear to be a predictive factor for IR injury or graft survival in liver transplant recipients.