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Related Concept Videos

Data Validation01:03

Data Validation

Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...
Data Validation01:15

Data Validation

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Key parameters for method validation include:
Frames01:30

Frames

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Framing Effects03:26

Framing Effects

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Quality Assurance01:19

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Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
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Related Experiment Videos

FRAME and the validation process.

Michael Balls1, Richard Clothier

  • 1FRAME, Nottingham, UK. michael.balls@btopenworld.com

Alternatives to Laboratory Animals : ATLA
|January 29, 2010
PubMed
Summary
This summary is machine-generated.

FRAME has significantly contributed to establishing validation principles for in vitro tests. The organization emphasizes the need for parallel invalidation processes and ATLA

Related Experiment Videos

Area of Science:

  • Toxicology
  • Regulatory Science
  • In Vitro Testing

Background:

  • The FRAME organization has a history of involvement in developing validation principles.
  • Validation ensures the reliability and relevance of scientific procedures for specific purposes.

Purpose of the Study:

  • To summarize FRAME's historical contributions to validation principles and practices.
  • To review FRAME's participation in in vitro test validation studies.
  • To highlight the importance of invalidation processes and ATLA's role.

Main Methods:

  • Review of FRAME's historical involvement in validation.
  • Examination of participation in various validation studies.
  • Discussion of the need for invalidation and ATLA's role.

Main Results:

  • FRAME has played a key role in defining and applying validation principles.
  • Examples of participation in in vitro test validation studies are provided.
  • The necessity of a parallel invalidation process is emphasized.

Conclusions:

  • FRAME's work has been crucial in advancing the validation of in vitro tests.
  • Objective reporting and discussion through ATLA are vital for the validation process.