Related Experiment Video
Updated: Jun 16, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Three-year survival after first-ever ischemic stroke is predicted by initial stroke severity: A hospital-based study
Ku-Chou Chang1, Hsuei-Chen Lee, Mei-Chiun Tseng
1Division of Cerebrovascular Diseases, Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Clinical Neurology and Neurosurgery
|January 29, 2010
Summary
Initial stroke severity and age are key early predictors of 3-year survival after ischemic stroke. Severe strokes showed a slightly lower impact of age on survival outcomes.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Public Health
Background:
- First-ever ischemic stroke poses a significant mortality risk.
- Understanding early prognostic factors is crucial for patient management and outcomes.
Purpose of the Study:
- To determine 3-year survival rates and causes of death following a first-ever ischemic stroke.
- To stratify survival by initial stroke severity.
Main Methods:
- Prospective follow-up of 360 acute ischemic stroke patients from September 1998 to October 1999.
- Vital status and causes of death tracked via the National Death Registry until December 2002.
- Cox proportional hazards regression with bootstrap validation used to identify prognostic factors.
Main Results:
- 92 (25.6%) patients died during follow-up (mean 43.4 months).
- Cumulative case-fatality rates reached 25.6% by year 4.
- Age and stroke severity (NIHSS scores) were significant predictors of mortality; severe stroke (NIHSS 16-38) had a hazard ratio of 335.90.
Conclusions:
- Initial stroke severity and patient age are critical early prognostic indicators for 3-year survival post-ischemic stroke.
- The impact of age on survival was diminished in patients with severe strokes.
Related Concept Videos
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.