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The disinfection efficacy of MeniCare soft multipurpose solution against Acanthamoeba and viruses using stand-alone
Wayne Heaselgrave1, James Lonnen, Simon Kilvington
1Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Purpose:
To assess the disinfection efficacy of MeniCare Soft contact lens multipurpose solution against Acanthamoeba and viruses in suspension and when inoculated on to contact lenses and subjected to rub-and-rinse or no-rub-and-rinse care regimes.
Methods:
MeniCare Soft was challenged with Acanthamoeba spp trophozoites or cysts, herpes simplex virus (type 1), adenovirus (type 8), and poliovirus (type 2) and the log reduction in Acanthamoeba viability and viral infectivity determined over time. In addition, contact lenses were incubated with Acanthamoeba and viruses and the number of viable organisms determined after the lenses were processed using rub-and-rinse or no-rub-and-rinse care regimes followed by a 4 hr soaking time.
Results:
MeniCare Soft showed >3 log reduction against Acanthamoeba spp trophozoites and cysts after 6 hr exposure. Approximately 1 log reduction was found against the 3 viruses after 4 hr exposure. No surviving Acanthamoeba trophozoites or cysts were recovered from any of the contact lens tested when MeniCare Soft was used in a rub-and-rinse or no-rub-and-rinse care regimes (>5.0 log reduction). Rub-and-rinse regimen resulted in a 4.5 to 5.0 log reduction in viruses compared with 3.7 to 5.2 log when no-rub-and-rinse was used.
Conclusions:
MeniCare Soft showed effective disinfection efficacy against Acanthamoeba trophozoites and cysts using solution and regimen assays. The viruses were more resistant to disinfection in solution but were removed effectively from contact lenses using a rub-and-rinse or no-rub-and-rinse care regimen.
Insights
MeniCare Soft effectively disinfects contact lenses against Acanthamoeba and viruses. Both rub-and-rinse and no-rub-and-rinse methods removed Acanthamoeba and viruses from lenses, demonstrating strong disinfection efficacy.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Contact lens solutions play a crucial role in maintaining lens hygiene.
- Microbial contamination of contact lenses poses a significant risk of eye infections.
- Acanthamoeba and viruses are common pathogens associated with contact lens-related keratitis.
Purpose of the Study:
- To evaluate the disinfection effectiveness of MeniCare Soft multipurpose solution.
- To assess efficacy against Acanthamoeba and common viruses.
- To compare disinfection with rub-and-rinse versus no-rub-and-rinse contact lens care regimens.
Main Methods:
- MeniCare Soft was tested against Acanthamoeba (trophozoites/cysts) and viruses (HSV-1, AdV-8, PV-2) in suspension.
- Contact lenses inoculated with Acanthamoeba and viruses were subjected to rub-and-rinse or no-rub-and-rinse care.
- Organism viability and viral infectivity were quantified after exposure and processing.
Main Results:
- MeniCare Soft achieved >3 log reduction of Acanthamoeba within 6 hours.
- A ~1 log reduction of viruses was observed in suspension after 4 hours.
- No viable Acanthamoeba were recovered from lenses treated with MeniCare Soft (>5.0 log reduction).
- Viruses were effectively removed from lenses, with rub-and-rinse yielding 4.5-5.0 log reduction and no-rub-and-rinse yielding 3.7-5.2 log reduction.
Conclusions:
- MeniCare Soft demonstrates potent disinfection against Acanthamoeba in solution and on contact lenses.
- Viruses showed higher resistance in suspension but were effectively removed from lenses by both care regimens.
- The multipurpose solution is effective for maintaining contact lens hygiene against key microbial threats.
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