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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Interrelationship between aortic stiffness and proteinuria in chronic kidney disease
C R Pan1, M Roos, C Schmaderer
1Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Journal of Human Hypertension
|January 29, 2010
Summary
In chronic kidney disease (CKD) patients, aortic stiffness and proteinuria are generally linked. However, this association is lost in younger CKD patients with primary kidney disease, where aortic stiffness does not predict proteinuria.
Area of Science:
- Nephrology
- Cardiology
- Vascular Biology
Background:
- Aortic stiffness and proteinuria are recognized cardiovascular risk factors.
- Their association is well-established in the general population.
- The relationship in chronic kidney disease (CKD) patients requires further investigation.
Purpose of the Study:
- To investigate the association between aortic stiffness and proteinuria in patients with CKD.
- To determine if aortic stiffness predicts proteinuria in younger CKD patients with predominant sole renal disease.
Main Methods:
- Cross-sectional analysis of 144 patients with mild-to-severe CKD.
- Aortic stiffness measured by carotid-femoral pulse wave velocity (C-F PWV).
- Proteinuria assessed by urine protein-creatinine ratio (P-C ratio).
- Stepwise linear regression used for analysis.
Main Results:
- A general association between C-F PWV and P-C ratio was observed in CKD patients.
- Younger patients (<50 years) with proteinuria predominantly had glomerulonephritis.
- These younger patients showed lower C-F PWV despite similar renal function compared to those without glomerulonephritis.
- C-F PWV did not predict proteinuria in young CKD patients with sole renal disease.
Conclusions:
- A general relationship between aortic stiffness and proteinuria exists in CKD patients.
- This relationship is absent in young CKD patients where renal disease is the primary cause of proteinuria.
- Carotid-femoral pulse wave velocity is not predictive of proteinuria in this specific subgroup.
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