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Methodology for inferences concerning familial correlations: a review
1Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada.
Journal of Clinical Epidemiology
|January 1, 1991
Summary
This review examines methods for estimating familial correlations, like sibling and parent-offspring relationships. It recommends using interval estimation more often for robust family study analyses.
Area of Science:
- Biostatistics
- Human Genetics
- Behavioral Genetics
Background:
- Familial correlations are crucial for understanding genetic and environmental influences on traits.
- Methodologic research in familial correlation inference has advanced significantly over 15 years.
- Estimating these correlations is key in various family studies.
Purpose of the Study:
- To review and compare methods for estimating sibling and parent-offspring correlations.
- To discuss the advantages and disadvantages of different methodologic approaches.
- To provide practical recommendations for family study analyses.
Main Methods:
- Systematic review of family studies published over a recent 2-year period.
- Analysis of various statistical inference procedures for familial correlations.
- Discussion of computational approaches for selected methods.
Main Results:
- Identified diverse methods for estimating sibling and parent-offspring correlations.
- Evaluated the strengths and weaknesses of different statistical approaches.
- Highlighted the need for more frequent use of interval estimation.
Conclusions:
- The choice of method impacts the reliability of familial correlation estimates.
- Interval estimation offers more comprehensive information than point estimates.
- Recommendations are provided to enhance the rigor of family study methodologies.