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Updated: Jun 16, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Left ventricular noncompaction.
Radha J Sarma1, Amar Chana, Uri Elkayam
1ABIM, Internal Medicine and Cardiovascular Diseases, University of Southern California, Keck School of Medicine, Division of Cardiovascular Medicine, Los Angeles, CA 90033, USA. sarma@usc.edu
Left ventricular noncompaction, an unclassified cardiomyopathy, lacks diagnostic consensus. Current research reviews its diagnosis, prognosis, and management in adults, suggesting a better outlook than previously thought.
Area of Science:
- Cardiology
- Genetics
- Medical Diagnostics
Background:
- Left ventricular noncompaction (LVNC) remains unclassified by the World Health Organization.
- Classified as a primary genetic cardiomyopathy by the American Heart Association in 2006.
- European Society of Cardiology's 2008 classification aligns with WHO, highlighting ongoing classification challenges.
Purpose of the Study:
- To review the current status of diagnosis, prognosis, and management of isolated left ventricular noncompaction in adults.
- To address the lack of consensus on diagnostic criteria and standardization.
- To improve awareness and understanding of this condition among clinicians.
Main Methods:
- Review of existing literature on left ventricular noncompaction.
- Analysis of diagnostic criteria based on cardiac imaging and autopsy findings.
- Evaluation of reported prognosis and therapeutic approaches.
Main Results:
- Diagnosis relies on morphologic features from cardiac imaging or autopsy due to lack of standardized criteria.
- The true prevalence of left ventricular noncompaction is unclear owing to diagnostic inconsistencies and limited clinician awareness.
- Prognosis appears to be more favorable than initially reported.
Conclusions:
- There is a critical need for consensus on diagnostic criteria for left ventricular noncompaction.
- Increased clinician awareness and standardized diagnostic approaches are essential.
- Despite challenges, the prognosis for isolated noncompaction in adults may be better than previously understood.
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