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Updated: Aug 1, 2026
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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
Lymphocytic hypophysitis with involvement of the cavernous sinus and hypothalamus
C E Nussbaum1, S H Okawara, L S Jacobs
1Division of Neurological Surgery, University of Rochester Medical Center, New York.
Neurosurgery
|March 1, 1991
Summary
Two cases of lymphocytic hypophysitis, a rare pituitary gland inflammation, are presented. Hypothalamic involvement leading to diabetes insipidus was a key feature, with one male patient showing cavernous sinus involvement.
Area of Science:
- Endocrinology
- Neurology
- Pathology
Background:
- Lymphocytic hypophysitis is an inflammatory condition affecting the pituitary gland.
- It is often associated with hormonal deficiencies and mass effect symptoms.
- Diagnosis can be challenging, often requiring biopsy confirmation.
Observation:
- Two male patients presented with lymphocytic hypophysitis.
- Both cases exhibited hypothalamic involvement, manifesting as diabetes insipidus.
- One patient demonstrated clinical and radiological evidence of cavernous sinus involvement.
Findings:
- Transsphenoidal biopsy confirmed the diagnosis in both cases.
- The presentation of cavernous sinus involvement in a male patient with lymphocytic hypophysitis is rare.
- Permanent diabetes insipidus secondary to hypothalamic involvement was noted.
Implications:
- Highlights the importance of considering lymphocytic hypophysitis in patients with pituitary inflammation and diabetes insipidus.
- Suggests that cavernous sinus involvement may occur in male patients with this condition.
- Emphasizes the diagnostic value of transsphenoidal biopsy.
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