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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
[Studies on flavones from Flos Chrysanthemi Indici]
Yi Tang1, Mei-Hua Gao, Mei-Cun Yao
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. tigertang@21cn.com
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|February 2, 2010
Summary
Seven chemical compounds were identified in Flos Chrysanthemi Indici, with four new compounds discovered. This research advances our understanding of this plant
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Pharmacognosy
Background:
- Flos Chrysanthemi Indici is traditionally used in medicine.
- Understanding its chemical composition is crucial for its medicinal applications.
Purpose of the Study:
- To isolate and identify the chemical constituents of Flos Chrysanthemi Indici.
Main Methods:
- Silica gel and Sephadex LH-20 column chromatography were used for isolation and purification.
- Physicochemical and spectral data were employed for structure identification.
Main Results:
- Seven compounds were isolated from the 80% ethanol extract.
- These compounds include luteolin, luteolin-7-O-beta-D-glucopyranoside, luteolin-7-O-(6"-O-acetyl)-beta-D-glucopyranoside, diosmetin, diosmetin-7-O-beta-D-glucopyranoside, eupatilin, and apigenin.
Conclusions:
- Compounds 3-6 (luteolin-7-O-(6"-O-acetyl)-beta-D-glucopyranoside, diosmetin, diosmetin-7-O-beta-D-glucopyranoside, and eupatilin) were isolated from Flos Chrysanthemi Indici for the first time.
- This study expands the known chemical profile of Flos Chrysanthemi Indici.
