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[Clinical features and treatment of serious brainstem encephalitis caused by enterovirus 71 infection]

Xiao-Jun Liu1, Wei Li, Yu-Qin Zhang

  • 1Department of Neurology, Tianjin Children's Hospital, Tianjin 300074, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|February 2, 2010
PubMed

Insights

Enterovirus 71 (EV71) causes severe brainstem encephalitis in young children, often presenting with fever, vomiting, and limb twitching. Early recognition of complications like pulmonary edema is crucial for effective treatment.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Virology

Context:

  • Enterovirus 71 (EV71) is a significant cause of neurological disease in children.
  • Severe brainstem encephalitis is a rare but serious complication of EV71 infection.
  • Understanding the clinical spectrum of EV71 brainstem encephalitis is essential for timely diagnosis and management.

Purpose:

  • To investigate the clinical characteristics of severe brainstem encephalitis in children infected with EV71.
  • To evaluate the treatment strategies employed for these patients.
  • To identify key clinical features and potential complications associated with EV71-induced brainstem encephalitis.

Summary:

  • Retrospective review of 32 children hospitalized with EV71 brainstem encephalitis.
  • Common symptoms included prolonged fever, vomiting, and limb twitching, predominantly in children under 3 years old.
  • Pulmonary edema/hemorrhage occurred in 8 patients, necessitating interventions like mechanical ventilation and inotropic agents.

Impact:

  • Highlights vegetative nerve dysfunction as a primary clinical manifestation.
  • Emphasizes the critical importance of early detection and management of pulmonary complications.
  • Informs clinical practice for managing severe EV71 infections in pediatric populations.
Abstract

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