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Updated: Jun 16, 2026

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Published on: May 18, 2016
Hemozoin: malaria's "built-in" adjuvant and TLR9 agonist
1Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, 81675 München, Germany. hermann.wagner@mikrobio.med.tum.de
Abstract:
The "built-in" adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a "built-in" adjuvant.
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