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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Training Dogs for Awake, Unrestrained Functional Magnetic Resonance Imaging
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Published on: October 13, 2019

Noninvasive functional MRI in alert monkeys.

Krishna Srihasam1, Kevin Sullivan, Tristram Savage

  • 1Department of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, MA 02115, USA.

Neuroimage
|February 2, 2010
PubMed
Summary
This summary is machine-generated.

Researchers developed a noninvasive vacuum helmet to immobilize monkey heads for functional magnetic resonance imaging (fMRI) studies. This method is as effective as invasive head posts, offering a safer alternative for brain research.

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Area of Science:

  • Neuroscience
  • Medical Imaging

Background:

  • Functional magnetic resonance imaging (fMRI) is crucial for studying brain function in humans and non-human primates.
  • Investigating primate brains with fMRI presents challenges due to small brain size and animal behavior.
  • Current methods often involve invasive surgical implants (head posts) for head stabilization.

Purpose of the Study:

  • To develop a noninvasive technique for immobilizing monkey heads during fMRI scans.
  • To provide a safer and more practical alternative to surgically implanted head posts.

Main Methods:

  • A custom-fitted plastic helmet with a chin strap was designed.
  • Mild suction from a vacuum blower was used to secure the monkey's head.
  • The vacuum helmet system was tested on trained monkeys during fMRI scanning.

Main Results:

  • The vacuum helmet method proved to be completely noninvasive.
  • No adverse effects were observed after several months of repeated use.
  • Head motion in monkeys using the vacuum helmet was comparable to those with traditional head posts.

Conclusions:

  • The vacuum helmet system offers an effective and noninvasive solution for head stabilization in monkey fMRI.
  • This technique reduces the risks and maintenance associated with invasive implants.
  • It facilitates more accessible and ethical primate brain research using fMRI.