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Updated: Jun 16, 2026

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Published on: August 21, 2017
Acute motor and sensory axonal neuropathy and concomitant encephalopathy during tumor necrosis factor-alpha
Anthony Faivre1, Jérome Franques, Andre Maues De Paula
1Hôpital d'Instruction des Armées Sainte-Anne, Service de Neurologie, Boulevard Ste-Anne, BP 20545 83041 Toulon cedex 9, France; Service de Neurologie et Maladies Neuromusculaires, Centre de Référence national pour les Maladies Neuromusculaires et la SLA, Hôpital la Timone, 264 boulevard St-Pierre, 13385 Marseille cedex 05, France.
Abstract:
A woman with Crohn's disease developed acute neuropathy and concomitant encephalopathy while being treated with infliximab. The etiological investigations were negative. Infliximab was stopped and she was given four series of polyvalent immunoglobulin injections. Eighteen months later, the encephalitic symptoms had disappeared and the neuropathic symptoms were less severe. TNF-alpha antagonists have been previously blamed for triggering neurological disorders, but no cases of acute neuropathy concomitant with encephalopathy have been reported so far.
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